Rhodium‐Catalysed Reductive Amination for the Synthesis of Tertiary Amines
نویسندگان
چکیده
منابع مشابه
Protecting-group-free synthesis of amines: synthesis of primary amines from aldehydes via reductive amination.
New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of aldehydes and hemiacetals, primary amines were selectively prepared with no or minimal formation of the usual secondary and tertiary amine byproduct. The methodology was performed on a range of functionalized aldehyde substrates, includi...
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The first one-pot selective synthesis of unsymmetric tertiary amines is reported by the amination of two types of alcohols with primary amines via the development of a simple CuAlOx-HT catalyst and enables the synthesis of unsymmetric amines in a wide variety of primary amines and alcohols.
متن کاملReductive amination of tertiary anilines and aldehydes.
An unprecedented oxidant-mediated reductive amination of tertiary anilines and aldehydes without external reducing agents was developed via the nucleophilic attack of the oxygen atom of the carbonyl group to in situ generated iminium ions, in which tertiary anilines were used as both nitrogen source and reducing agent for the first time.
متن کاملnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
Highly enantioselective hydrogen-transfer reductive amination: catalytic asymmetric synthesis of primary amines.
Optically active amines are attracting increasing interest in the food, agrochemical, and pharmaceutical industries as building blocks for novel compounds and as templates for asymmetric synthesis. One of the most common methods for preparing amines is the reductive amination of carbonyl compounds. We have successfully explored the rhodiumcatalyzed asymmetric reductive amination with hydrogen a...
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2020
ISSN: 1615-4150,1615-4169
DOI: 10.1002/adsc.202000746